Topical Treatments for Hidradenitis Suppurativa

Topical treatments are uniquely advantageous in that they can be applied directly to the skin, thus reducing systemic side effects. Topical antibiotics and keratolytics, or agents which promote the breakdown of the cell to cell bonds, have been used in localized disease or as an adjunctive treatment in more severe HS.

Topical clindamycin (antibiotic), and resorcinol, a topical keratolytic, are two agents which are supported by clinical studies, but patients report efficacy of benzoyl peroxide as well.1

  • Alavi A, Kirsner RS. Local wound care and topical management of hidradenitis suppurativa. J Am Acad Dermatol. 2015;73(5 Suppl 1):S55-61.